Therefore, buprenorphine tablets are also made to contain naloxone to discourage such incidences. Since naloxone acts by blocking opioid receptors, this may seem contrary to the work of buprenorphine. However, the naloxone will not be activated when Suboxone, the combination drug formed, is taken by the sublingual method. If this tablet is still crushed and snorted, naloxone activates, thereby inducing opioid withdrawal symptoms. Some of these symptoms are muscle aches, insomnia, anxiety, diarrhea, and nausea/vomiting. The high risk of severe dependence that leads to overdose is also another problem arising from snorting buprenorphine.
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